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KMID : 1189420080210030069
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2008 Volume.21 No. 3 p.69 ~ p.81
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The anti-allergic effect of SESHINGO(SSG)
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Kim Min-Ae
Ko Woo-Shin
Yoon Hwa-Jung
Kim Mi-Bo
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Abstract
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Objective : The purpose of this study was find out the anti-allergic effects of SESHINGO on the allergic rhinitis.
Methods : Cell viability was evaluated by the MTT assay. Cells were treated with the indicated concentration of SSG. TNF-α concentration was measured from cell supernatants using ELISA method. IL-4 concentration was measured from cell supernatants using ELISA method.IFN-γ concentration was measured from cell supernatants using ELISA method. Total RNA was isolated, TNF-α and IL-4 mRNA expression was detected by RT-PCR analysis Total RNA was isolated, COX-1, COX-2 mRNA was analyzed by RT-PCR analysis.
Results : 1. β-hexosaminidase release in RBL-2H3 cells were decresed by SESHINGO attentively . 2. Secreting ration of TNF-α was restrained in RBL-2H3 cells by SESHINGO attentively. 3. Secreting ration of IL-4 was restrained in RBL-2H3 cells by SESHINGO attentively 4. Revelation of TNF-α mRNA was decresed in RBL-2H3 cells as concetration. 5. Revelation of.IL-4 mRNA was decresed in RBL-2H3 cells as concetration. 6. Revelation of COX-2 mRNA was decresed in RBL-2H3 cells.
Conclusion : According to above results, to evaluate the effect of SSG on the anti-allergic effects.
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KEYWORD
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SESHINGO, allergic effects
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